But they ended up sharing a point with Kevin Kisner and Phil Mickelson in the final match of the day, in which Mickelson missed a seven-foot putt at the 18th that could have given the Americans yet another win.
Steve Stricker's side claimed four-and-a-half points out of five on day two in New Jersey to leave Nick Price's global team staring down the barrel of a 10th defeat from 12 contests since the competition was first held in 1994.
After an opening ceremony that included the attendance of former U.S. Presidents Bill Clinton, George W. Bush and Barack Obama, Day One of the Presidents Cup officially began and the attention went back to golf itself.
The Americans came within one match of winning the Presidents Cup - on Saturday. The U.S. rolled and could have won all five, if a Jordan Spieth putt had juuust fallen in the edge of the cup on the 18th.
Opening the second day with a 3.5-1.5 lead, American captain Steve Stricker made very few changes to his lineup.
Absolutely, we say, and as worldwide captain Nick Price pointed out, only 10 of the possible 30 points have been accounted for after the initial foursomes and four-ball sessions.
"I don't really think much about", Mickelson added of matching the record.
Sunday will be singles matches, with one USA player going head-to-head against an worldwide player.
Former world number one Spieth and fellow American Reed combined to beat Emiliano Grillo and Kim Si-woo as reigning champions the United States took a 3.5 - 1.5 lead over the Internationals in New Jersey on Thursday.
KEY STATISTIC: There were 16 holes won on the back nine - 13 by the Americans. Kisner took the par-4 11th with a birdie then nailed a clutch 20-footer on 15 to square the match late. - Justin Thomas, on being the first US team to beat Oosthuizen and Grace.
It's hard to believe that it was only a couple of weeks ago that we were debating whether or not Phil Mickelson deserved a spot on this year's Presidents Cup team. But after two days of give and take, it's been the back half of Stricker's lineup that has turned this year's matches into what is shaping up to be another blowout.
Lahiri and Si Woo Kim delivered the only victory for the global team over two sessions, and the Americans poured it on. The Australian duo of Day/Leishman will once again draw Mickelson/Kisner Friday in a four-ball match.
"You know, the guys are trying".