Jelena Ostapenko defeated Elina Svitolina 6-3, 7-6 (8-6) to reach her first ever Wimbledon quarterfinal.
He has now accounted for the defending champion in each of the last two years at Wimbledon, after beating Djokovic in the third round last year.
In today's quarter-finals he tackles American Sam Querrey, who sits tied for second in the ace stakes at Wimbledon after rifling down 99 clean service winners in four matches. This is Murray's 26th grand-slam quarter-final and only Querrey's second, but the Scot has been upset by big servers at previous grand-slam events.
Next up for Murray is big-serving Californian Sam Querrey, who toppled Djokovic here a year ago.
"I've played so many matches on this court but it's the first games that I remember the best, like losing to David Nalbandian in my first tournament".
Lleyton Hewitt would love to see Roger Federer and Andy Murray go at it in another Wimbledon final on Sunday.
The two-time Wimbledon victor is bidding to reach the last-eight at the Slams for a 32nd time against a player who has gone that far just once - at the 2008 US Open.
The World No.1 will enter the match as the overwhelming favourite and will benefit from his straight sets victories, in comparison to Querrey who has experienced some drawn-out matches so far. This is Querrey's second career quarterfinal, as he made the quarters in last years Wimbledon.
Murray, a two-time champion at the All England Club, has now lost his last four five-set matches overall.
It's telling that the American whose name and face is advertised on billboards and posters around SW19 is a guy who retired 11 years ago, Andre Agassi. "I'm going to enjoy this one a little bit longer, rest tomorrow and do my best to get ready for the semis".
"He has a tough style to play against", said Murray. He's got a good team around him, good on him. Murray, according to Wikipedia, has won 43 of his 52 matches against French players.
For 12 grinding years and 42 Grand Slam tournaments and $8 million in prize money, Sam Querrey has roamed the Earth, somewhat famous and somewhat not.
If there is to be a first-time Wimbledon victor, Hewitt would lean towards Croatia's former US Open champion Marin Cilic, who could face Murray in the last four.
8 meetings have come between Murray and Querrey with all but one of those being won by Murray.
Querrey, one of the most affable and popular players on the Tour, steeled himself for the kill, finishing it with a 118mph ace beyond Murray's right arm, which hung motionless by his side.